无血性
习得的无助感
神经科学
缰
重性抑郁障碍
萧条(经济学)
病理生理学
心理学
医学
中枢神经系统
发展心理学
内科学
认知
多巴胺
宏观经济学
经济
作者
Yan Yang,Hao Wang,Ji Hu,Hailan Hu
标识
DOI:10.1016/j.conb.2017.10.024
摘要
Depression is a devastating disorder with a combination of diverse symptoms such as low self-esteem, lack of motivation, anhedonia, loss of appetite, low energy, and discomfort without a clear cause. Depression has been suggested to be the result of maladaptive changes in specific brain circuits. Recently, the lateral habenula (LHb) has emerged as a key brain region in the pathophysiology of depression. Increasing evidence from rodent, non-human primate and human studies indicates that the aberrant activity of the LHb is associated with depressive symptoms such as helplessness, anhedonia, and excessive negative focus. Revealing the molecular, cellular and circuit properties of the LHb will help explain how abnormalities in LHb activity are linked to depressive disorders, and shed light on developing novel strategies for depression treatment.
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