成纤维细胞生长因子受体
细胞生物学
癌症研究
生物
mTORC1型
增强子
成纤维细胞生长因子
PI3K/AKT/mTOR通路
信号转导
受体
生物化学
基因
转录因子
作者
Krystal A. Orlando,Paul A. Wade
标识
DOI：10.1038/s41556-021-00782-y
摘要
FGFR-altered triple negative breast cancer (TNBC) develops adaptive resistance to FGFR inhibitor therapy. A new study shows that sustained FGFR inhibition causes SWI/SNF complex eviction at YAP-recruited enhancers followed by increased mTORC1 activity. Dual inhibition of YAP or mTORC1 and FGFR has a synergistic effect on tumour growth.
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