U-shaped association between dietary copper intake and new-onset hypertension

医学 血压 内科学 舒张期 心脏病学
作者
Panpan He,Huan Li,Xianhui Qin,Mengyi Liu,Zhuxian Zhang,Yuanyuan Zhang,Chun Zhou,Xianhui Qin,Ziliang Ye,Qimeng Wu,Jianping Jiang,Guobao Wang,Min Liang,Jing Nie,Fan Fan Hou,Xianhui Qin
出处
期刊:Clinical Nutrition [Elsevier BV]
卷期号:41 (2): 536-542 被引量:21
标识
DOI:10.1016/j.clnu.2021.12.037
摘要

To investigate the relationship of dietary copper intake with new-onset hypertension among Chinese adults.A total of 12,245 participants who were free of hypertension at baseline from the China Health and Nutrition Survey (CHNS) were included. Dietary intake was measured by 3 consecutive 24-h dietary recalls combined with a household food inventory. New-onset hypertension was defined as systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg or diagnosed by a physician or under antihypertensive treatment during the follow-up.During a median follow-up of 6.1 years, 4304 participants developed new-onset hypertension. Overall, the associations between dietary copper intake and new-onset hypertension followed a U-shape (P for nonlinearity <0.001). The risk of new-onset hypertension significantly decreased with the increment of dietary copper intake (per SD increment: HR, 0.71; 95% CI, 0.57-0.88) in participants with copper intake <1.57 mg/day, and increased with the increment of dietary copper intake (per SD increment: HR, 1.09; 95% CI: 1.07-1.12) in participants with copper intake ≥1.57 mg/day.There was a U-shaped association between dietary copper intake and new-onset hypertension in general Chinese adults, with an inflection point at about 1.57 mg/day. Our results emphasized the importance of maintaining optimal copper intake levels for the primary prevention of hypertension.
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