医学
粘膜黑色素瘤
副鼻窦
鼻腔
头颈部
佐剂
放射治疗
免疫疗法
黑色素瘤
免疫原性
疾病
肿瘤科
外科
内科学
癌症
免疫系统
癌症研究
免疫学
作者
Pablo Nenclares,Kevin J. Harrington
标识
DOI:10.1016/j.coms.2021.11.008
摘要
Head and neck mucosal melanomas are uncommon and aggressive malignancies that arise mainly in the nasal cavity and paranasal sinuses, with the next commonest site being the oral cavity. The mainstay of treatment is radical surgical resection. Adjuvant radiotherapy improves locoregional control but does not improve overall survival. Systemic treatment with immunotherapy or targeted therapies can offer scope for modifying the course of the disease in both the adjuvant and the recurrent and metastatic setting. Further understanding of the genomic landscape and factors regulating immunogenicity will lead to further therapeutic opportunities in this challenging disease.
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