Microbiota diversity in nonalcoholic fatty liver disease and in drug-induced liver injury

非酒精性脂肪肝 脂肪肝 肠道菌群 内科学 生物 肝损伤 胃肠病学 微生物学 医学 疾病 生物化学
作者
C. Rodríguez,Bernard Taminiau,Alberto García-García,Alejandro Cueto,Mercedes Robles‐Díaz,Aida Ortega‐Alonso,Flores Martín‐Reyes,Georges Daube,Judith Sanabria‐Cabrera,Miguel Jiménez‐Pérez,M. Isabel Lucena,Raúl J. Andrade,Eduardo Garcı́a-Fuentes,Miren García‐Cortés
出处
期刊:Pharmacological Research [Elsevier BV]
卷期号:182: 106348-106348 被引量:55
标识
DOI:10.1016/j.phrs.2022.106348
摘要

The gut microbiota could play a significant role in the progression of nonalcoholic fatty liver disease (NAFLD); however, its relevance in drug-induced liver injury (DILI) remains unexplored. Since the two hepatic disorders may share damage pathways, we analysed the metagenomic profile of the gut microbiota in NAFLD, with or without significant liver fibrosis, and in DILI, and we identified the main associated bacterial metabolic pathways. In the NAFLD group, we found a decrease in Alistipes, Barnesiella, Eisenbergiella, Flavonifractor, Fusicatenibacter, Gemminger, Intestinimonas, Oscillibacter, Parasutterella, Saccharoferementans and Subdoligranulum abundances compared with those in both the DILI and control groups. Additionally, we detected an increase in Enterobacter, Klebsiella, Sarcina and Turicibacter abundances in NAFLD, with significant liver fibrosis, compared with those in NAFLD with no/mild liver fibrosis. The DILI group exhibited a lower microbial bacterial richness than the control group, and lower abundances of Acetobacteroides, Blautia, Caloramator, Coprococcus, Flavobacterium, Lachnospira, Natronincola, Oscillospira, Pseudobutyrivibrio, Shuttleworthia, Themicanus and Turicibacter compared with those in the NAFLD and control groups. We found seven bacterial metabolic pathways that were impaired only in DILI, most of which were associated with metabolic biosynthesis. In the NAFLD group, most of the differences in the bacterial metabolic pathways found in relation to those in the DILI and control groups were related to fatty acid and lipid biosynthesis. In conclusion, we identified a distinct bacterial profile with specific bacterial metabolic pathways for each type of liver disorder studied. These differences can provide further insight into the physiopathology and development of NAFLD and DILI.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
自信雅琴发布了新的文献求助10
1秒前
anna发布了新的文献求助10
4秒前
CodeCraft应助Lu采纳,获得10
5秒前
5秒前
5秒前
Bressanone发布了新的文献求助10
6秒前
妙蛙完成签到,获得积分10
7秒前
8秒前
111111111发布了新的文献求助10
9秒前
妙蛙发布了新的文献求助10
11秒前
12秒前
爱笑紫菜发布了新的文献求助30
14秒前
14秒前
15秒前
李爱国应助111111111采纳,获得10
15秒前
tay发布了新的文献求助10
16秒前
科研通AI5应助ffff采纳,获得10
17秒前
过氧化氢发布了新的文献求助30
19秒前
感动黄豆发布了新的文献求助10
20秒前
钱宇成发布了新的文献求助10
20秒前
YJ888发布了新的文献求助10
20秒前
vincen91完成签到,获得积分10
24秒前
Leach完成签到 ,获得积分10
25秒前
长乐完成签到,获得积分10
26秒前
FashionBoy应助院士人启动采纳,获得10
30秒前
31秒前
31秒前
AptRank完成签到,获得积分10
32秒前
量子星尘发布了新的文献求助10
32秒前
焦糖布丁的滋味完成签到,获得积分10
32秒前
33秒前
隐形的觅波完成签到 ,获得积分10
34秒前
儒雅南风完成签到 ,获得积分10
35秒前
小马甲应助科研通管家采纳,获得10
36秒前
打打应助科研通管家采纳,获得10
36秒前
科研通AI5应助科研通管家采纳,获得10
36秒前
Orange应助科研通管家采纳,获得10
36秒前
Bio应助科研通管家采纳,获得30
36秒前
慕青应助科研通管家采纳,获得10
36秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989115
求助须知:如何正确求助?哪些是违规求助? 3531367
关于积分的说明 11253688
捐赠科研通 3269986
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882078
科研通“疑难数据库(出版商)”最低求助积分说明 809105