碱性磷酸酶
格列本脲
天冬氨酸转氨酶
丙氨酸转氨酶
内科学
普萘洛尔
医学
胆红素
内分泌学
化学
药理学
酶
生物化学
糖尿病
作者
Hina Abrar,Adeel Arsalan,Hina Yasin,Syed Ijaz Hussain Zaidi,Sadaf Ibrahim,Kiran Qadeer,Hira Naeem,Kaneez Fatima,Hina Tabassum,Syed Muhammad Zulfiqar Hyder Naqvi
出处
期刊:PubMed
日期:2020-07-01
摘要
Glibenclamide (GBC) has been associated with hepatotoxicity in humans. This study conducted on rabbits to evaluate the hepatotoxicity of GBC alone and in combination therapy with propranolol (PPL). Liver enzymes like alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyltransferase (γ-GT) and bilirubin (BRB) are used to evaluate hepatotoxicity associated with GBC. Histological findings, micrometry and scanning electron microscopy (SEM) used to find hepatotoxicity by GBC and with PPL. GBC caused significant elevation of liver functions as compared to control (p<0.005). PPL reduced the level of serum ALT, ALP, γGT and BRB when administered with GBC (p<0.005). The results prevailed that there is a significant change in hepatic cells structure and significant change in its diameter of nucleus (p<0.05). The necrosis and granuloma with decreased in number of hepatic cells were observed in GBC treated rabbits. However, the combination of GBC with PPL has shown healthy and nearly similar structure as that of controlled group and confirmed by SEM microscopy. PPL reduced the blood flow to hepatic portal system and thus, avoid the noxious substances to liver. It is affirmed that the use of PPL offered beneficial effect on hepatotoxic drugs.
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