枸杞
树皮(声音)
类固醇
化学
立体化学
皂甙元
传统医学
生物
生物化学
医学
激素
生态学
病理
替代医学
作者
Ya-Wen An,Zhi-Lai Zhan,Jing Xie,Ya‐Nan Yang,Jian‐Shuang Jiang,Zi‐Ming Feng,Fei Ye,Pei‐Cheng Zhang
标识
DOI:10.1021/acs.jnatprod.5b01087
摘要
Lyciumsterols A–K (1–11), 11 new octahydroxylated C21 steroids, were isolated from the root bark of Lycium chinense, along with 15 known compounds. Characterization of these C21 steroids showed the presence of eight hydroxy groups on the C21 steroid skeleton with a (2E,4E)-5-phenyl-2,4-pentadienoate group at C-12 or C-20 and various 2,6-deoxy sugar residues at C-3. The structures of these compounds were elucidated using spectroscopic data interpretation. Compounds 2, 3, and 7 exhibited dose-dependent protective effects on pancreatic islet cells and may help to improve cell viability. In addition, it was found that compounds 7, 8, 9, and 11 exhibited autophagy activation.
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