阿格林
突触发生
神经科学
再生(生物学)
突触
医学
杜氏肌营养不良
突触形成
神经肌肉接头
生物
受体
细胞生物学
乙酰胆碱受体
内科学
作者
Katherine A. Deyst,Jun Ma,Justin R. Fallon
出处
期刊:Neurosurgery
[Oxford University Press]
日期:1995-07-01
卷期号:37 (1): 71-77
被引量:7
标识
DOI:10.1227/00006123-199507000-00011
摘要
One of the foremost challenges to repairing damage after stroke, trauma, or disease is the regeneration of synaptic connections between neurons. Here, we consider recent strides in our understanding of the molecular basis of synapse formation and regeneration. We will focus on the protein agrin, a key player in synaptogenesis at neuromuscular junctions and perhaps at central nervous system synapses as well. Insights into agrin and its receptor could guide the development of rational therapies to combat neuronal degeneration. We will also consider recent surprising and provocative data linking the mechanisms of synapse formation and the cellular pathology in Duchenne muscular dystrophy.
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