Pharmacokinetics of Novel Erythropoiesis Stimulating Protein Compared with Epoetin Alfa in Dialysis Patients

药代动力学 促红细胞生成素 医学 艾博汀阿尔法 腹膜透析 分配量 丸(消化) 红细胞生成 泌尿科 透析 内科学 半衰期 内分泌学 贫血
作者
Iain C. Macdougall,Stephen J. Gray,Orlaith Elston,Cormac Breen,B S Jenkins,Jeff Browne,Joan C. Egrie
出处
期刊:Journal of The American Society of Nephrology 卷期号:10 (11): 2392-2395 被引量:385
标识
DOI:10.1681/asn.v10112392
摘要

Abstract. Novel erythropoiesis stimulating protein (NESP) is a hyperglycosylated analogue of recombinant human erythropoietin (Epoetin) which has an increased terminal half-life in animal models. The aim of this study was to extend these observations to humans. Using a double-blind, randomized, cross-over design, the single-dose pharmacokinetics of Epoetin alfa (100 U/kg) and an equivalent peptide mass of NESP were compared following intravenous bolus in 11 stable peritoneal dialysis patients. This was followed by an open-label study to determine the single-dose pharmacokinetics of an equivalent peptide mass of NESP by subcutaneous injection in six of these patients. The mean terminal half-life for intravenous NESP was threefold longer than for intravenous Epoetin (25.3 versus 8.5 h), a difference of 16.8 h (95% confidence interval, 9.4 to 24.2 h, P = 0.0008). The area under the serum concentration—time curve was significantly greater for NESP (291.0 ± 7.6 ng · h per ml versus 131.9 ± 8.3 ng · h per ml; mean ± SEM; P < 0.0005), and clearance was significantly lower (1.6 ± 0.3 ml/h per kg versus 4.0 ± 0.3 ml/h per kg; mean ± SEM; P < 0.0005). The volume of distribution was similar for NESP and Epoetin (52.4 ± 2.0 ml/kg versus 48.7 ± 2.1 ml/kg; mean ± SEM). The mean terminal half-life for subcutaneous NESP was 48.8 h. The peak concentration of subcutaneous NESP was approximately 10% of that following intravenous administration, and bioavailability was approximately 37% by the subcutaneous route. The longer half-life of NESP is likely to confer a clinical advantage over Epoetin by allowing less frequent dosing in patients treated for anemia.

科研通智能强力驱动
Strongly Powered by AbleSci AI

祝大家在新的一年里科研腾飞
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
勤恳的糖豆完成签到,获得积分10
刚刚
李健应助张达采纳,获得10
1秒前
7秒前
平安喜乐完成签到 ,获得积分10
9秒前
心灵美海蓝完成签到,获得积分10
9秒前
10秒前
明天吃什么完成签到 ,获得积分10
16秒前
Chris完成签到 ,获得积分0
17秒前
dxx完成签到 ,获得积分20
19秒前
lz完成签到 ,获得积分10
20秒前
22秒前
26秒前
27秒前
友好若南完成签到,获得积分10
27秒前
轻松小之发布了新的文献求助10
28秒前
anioscal完成签到,获得积分10
29秒前
30秒前
怜熙完成签到 ,获得积分10
32秒前
kyj发布了新的文献求助10
33秒前
无聊的幻天发布了新的文献求助200
36秒前
kyj完成签到,获得积分10
36秒前
左友铭完成签到 ,获得积分10
37秒前
干净珊完成签到 ,获得积分10
38秒前
40秒前
李健应助hai采纳,获得10
41秒前
cocolu应助Amuro采纳,获得10
46秒前
热情的幻丝完成签到,获得积分10
46秒前
48秒前
51秒前
Ava应助小巧的诗双采纳,获得10
55秒前
洁净的发夹完成签到,获得积分10
56秒前
南庭完成签到 ,获得积分10
56秒前
Gauss应助星河圈揽采纳,获得30
58秒前
59秒前
在水一方应助optimist采纳,获得10
1分钟前
十里桃花不徘徊完成签到,获得积分10
1分钟前
00K发布了新的文献求助10
1分钟前
HKK发布了新的文献求助10
1分钟前
kk完成签到,获得积分20
1分钟前
123完成签到,获得积分10
1分钟前
高分求助中
Востребованный временем 2500
Production Logging: Theoretical and Interpretive Elements 2000
Kidney Transplantation: Principles and Practice 1000
The Restraining Hand: Captivity for Christ in China 500
The Collected Works of Jeremy Bentham: Rights, Representation, and Reform: Nonsense upon Stilts and Other Writings on the French Revolution 320
Encyclopedia of Mental Health Reference Work 300
脑血管病 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3371679
求助须知:如何正确求助?哪些是违规求助? 2989769
关于积分的说明 8737179
捐赠科研通 2673092
什么是DOI,文献DOI怎么找? 1464360
科研通“疑难数据库(出版商)”最低求助积分说明 677506
邀请新用户注册赠送积分活动 668824