超声
异硫氰酸盐
异硫氰酸苄酯
抗菌剂
溶解度
环糊精
异硫氰酸烯丙酯
热稳定性
化学
傅里叶变换红外光谱
有机化学
组合化学
核化学
化学工程
色谱法
工程类
作者
Shivani Uppal,Khushwinder Kaur,Rajendra Kumar,Nakshdeep Kaur Kahlon,Rachna Singh,S.K. Mehta
标识
DOI:10.1016/j.ultsonch.2017.04.007
摘要
The use of methodical and innovative sonication method has been explored for the fabrication of inclusion complex of Benzyl Isothiocyanate, a potential anticancer and -antimicrobial agent. The advancement involved investigation of inclusion behaviour, characterisation and an in-depth study of thermal and UV stability of Benzyl Isothiocyanate with cyclodextrins; β-CD and hp-β-CD. The sonication driven encompassment in cyclodextrins helped to overcome the hindrance of low solubility and high volatility. Investigations of physical and thermodynamic parameters using UV–visible spectroscopy, FTIR, XRD, TGA etc confirmed stability of inclusion complexes. Both β-CD and hp-β-CD based inclusion complexes retained the antimicrobial property of the free Benzyl Isothiocyanate, indicating their potential utility as antimicrobial agents. Haematological safety and cellular uptake data gives direction to in-depth analysis for its exploitation of anti-tumour activity.
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