白霉素类
鞘脂
背景(考古学)
生物
抗真菌
微生物学
计算生物学
药理学
两性霉素B
卡斯波芬金
生物化学
古生物学
作者
Rodrigo Rollin‐Pinheiro,Ashutosh Singh,Eliana Barreto‐Bergter,Maurizio Del Poeta
出处
期刊:Future Medicinal Chemistry
[Newlands Press Ltd]
日期:2016-08-01
卷期号:8 (12): 1469-1484
被引量:73
标识
DOI:10.4155/fmc-2016-0053
摘要
Invasive fungal infections have significantly increased in the last few decades. Three classes of drugs are commonly used to treat these infections: polyenes, azoles and echinocandins. Unfortunately each of these drugs has drawbacks; polyenes are toxic, resistance against azoles is emerging and echinocandins have narrow spectrum of activity. Thus, the development of new antifungals is urgently needed. In this context, fungal sphingolipids have emerged as a potential target for new antifungals, because their biosynthesis in fungi is structurally different than in mammals. Besides, some fungal sphingolipids play an important role in the regulation of virulence in a variety of fungi. This review aims to highlight the diverse strategies that could be used to block the synthesis or/and function of fungal sphingolipids.
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