Therapeutic Peptide Delivery: Fundamentals, Formulations, and Recent Advances

Recent advances in the field of peptide therapeutics have led to the design and synthesis of many promising peptides. However, research and development to provide safe, stable, efficacious, and patient compliant formulation plays a vital role in bringing peptide therapeutics to market. The conventional parenteral route has made scientific advances to overcome multiple barriers, leading to the approval of many peptide-based products via parenteral route of administration in recent years. In parallel, oral, pulmonary, transdermal, and other delivery routes have been extensively investigated to deliver peptides with improved patient compliance. This includes the use of novel strategies for developing delivery systems that can offer various advantages over conventional dosage forms. This chapter focuses on fundamentals, formulations, and recent advances for successful peptide delivery.