丝胶
氟尿嘧啶
化学
人口
胶体
纳米技术
材料科学
色谱法
化学工程
癌症
有机化学
医学
复合材料
内科学
丝绸
环境卫生
工程类
作者
Agnese Gagliardi,Nicola Ambrosio,Silvia Voci,Maria Cristina Salvatici,Massimo Fresta,Donato Cosco
标识
DOI:10.1016/j.molliq.2022.120344
摘要
In this study, for the first time, 5-Fluorouracil was entrapped in blend nanosystems made up of sericin and zein by means of an easy and economic approach. The nanoblends showed mean sizes of 100–150 nm, a monodispersed population, high stability in serum, 6 months storage stability and the possibility to be freeze-dried. In addition, the colloidal blend systems showed a greater ability to hold the bioactive compound as compared to the zein nanosystems, and promoted a gradual release of the drug. The nanoblend preserved the pharmacological activity of 5-Fluouracil against cancer cells, suggesting the potential application of this novel formulation in antitumor therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI