自愈水凝胶
原位
结晶
复合数
化学工程
材料科学
化学
复合材料
高分子化学
有机化学
工程类
作者
Marcela Mihai,Elena-Daniela Lotos,Mayer Zaharia,Florin Bucătariu,Ana‐Lavinia Vasiliu
标识
DOI:10.1021/acs.cgd.3c01518
摘要
Composite hydrogels based on polysaccharides are of high interest in the biomedical field due to their superior characteristics resulting from the combination of constituents' properties. Herein, we propose a new method for obtaining calcium alginate-calcium carbonate hydrogels, starting from an insoluble calcium alginate (ACa) aqueous dispersion which acts as a crystallization medium for the in situ growth of CaCO3 through ammonium diffusion in a hermetically closed desiccator. To further enhance the applicability of the proposed method, three-component composite hydrogels were obtained using ACa and nonstoichiometric polyelectrolyte complexes (NPECs) as the crystallization medium. The latter were obtained prior by the titration of a zein solution with two polysaccharides, namely, sodium alginate and chondroitin sulfate A, in different molar ratios. The resulting composite hydrogels were freeze-dried and further cross-linked with BTCDA. All of the hydrogels were characterized by SEM, XRD, and FTIR–ATR, and a MTS assay indicated a high cell viability for the cross-linked samples. All of the hydrogels obtained showed a highly organized network with uniform pores, having calcite as the main CaCO3 polymorph.
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