Current iontronics are restricted by mostly using a single-species ion as the signal carrier. Chen et al. reported in Science that a biphasic gel iontronic could regulate multi-ionic transmission, which was correlated with the energy barriers at the cascade heterointerface and the ionic dehydration energies. This work may inspire new ideas of constructing materials with defect-free heterointerface for ion sieving-related applications. Current iontronics are restricted by mostly using a single-species ion as the signal carrier. Chen et al. reported in Science that a biphasic gel iontronic could regulate multi-ionic transmission, which was correlated with the energy barriers at the cascade heterointerface and the ionic dehydration energies. This work may inspire new ideas of constructing materials with defect-free heterointerface for ion sieving-related applications.