迈克尔反应
多米诺骨牌
环加成
全合成
化学
烯酮
组合化学
立体化学
催化作用
有机化学
作者
Jiayang Zhang,Yan Xu,Qing‐Bao Zhang,Fang Wang,Bin Yang,Yang Yang
标识
DOI:10.1002/advs.202308164
摘要
Abstract The collective total syntheses of (±)‐hosieines A–C with a cage‐like tetracyclic framework have been realized, which includes the first syntheses of hosieines B‐C. The key strategy of the synthesis employs a one‐pot domino reaction that involves Cu‐catalyzed [3+2] cycloaddition, 1,6‐enone formation, and 1,6‐aza‐Michael addition forming the 5/6/6‐aza‐tricyclic skeleton. Other salient synthetic tactics comprise a challenging double bond migration and a 1,4‐aza‐Michael addition reaction to afford the tetracyclic framework.
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