Lipopolysaccharide accelerates tryptophan degradation in the ovary and the derivative kynurenine disturbs hormone biosynthesis and reproductive performance

犬尿氨酸 脂多糖 黄体 生物 内分泌学 内科学 激素 排卵 犬尿氨酸途径 卵巢 分解代谢 化学 生物化学 色氨酸 新陈代谢 医学 氨基酸
作者
Jie Shen,Weimin Zhao,Juanru Cheng,Jinhua Cheng,Lei Zhao,Chaohui Dai,Yanfeng Fu,Bixia Li,Zhe Chen,Deshun Shi,Hui Li,Yanfei Deng
出处
期刊:Journal of Hazardous Materials [Elsevier]
卷期号:458: 131988-131988 被引量:2
标识
DOI:10.1016/j.jhazmat.2023.131988
摘要

Lipopolysaccharide (LPS), also known as endotoxin, is a component of the outer membrane of gram-negative bacteria. LPS is released into the surrounding environment during bacterial death and lysis. Due to its chemical and thermal stability, LPS can be detected anywhere and easily exposed to humans and animals. Previous studies have shown that LPS causes hormonal imbalances, ovarian failure, and infertility in mammals. However, the potential mechanisms remain unclear. In this study, we investigated the effects and mechanisms of LPS on tryptophan degradation, both in vivo and in vitro. The effects of kynurenine, a tryptophan derivative, on granulosa cell function and reproductive performance were explored. Results showed that p38, NF-κB, and JNK signaling pathways were involved in LPS-induced Ido1 expressions and kynurenine accumulation. Furthermore, the kynurenine decreased estradiol production, but increased granulosa cell proliferation. In vivo, experiments showed that kynurenine decreased estradiol and FSH production and inhibited ovulation and corpus luteum formation. Additionally, pregnancy and offspring survival rates decreased considerably after kynurenine treatment. Our findings suggest that kynurenine accumulation disrupts hormone secretion, ovulation, corpus luteal formation, and reproductive performance in mammals.
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