Understanding osteokine biology

Bone is an endocrine organ that participates in whole-body homeostasis. The biology of bone-derived osteokines, however, remains unclear. Liang et al. integrate experimental and computational methods to discover new osteokines, establish their cell of origin and target site, and study their role in aging and during mechanical stress. Bone is an endocrine organ that participates in whole-body homeostasis. The biology of bone-derived osteokines, however, remains unclear. Liang et al. integrate experimental and computational methods to discover new osteokines, establish their cell of origin and target site, and study their role in aging and during mechanical stress. An integrated multi-omics analysis reveals osteokines involved in global regulationLiang et al.Cell MetabolismApril 3, 2024In BriefLiang et al. use an integrated multi-omics approach to identify osteokines under physiological, aging, and mechanical loading/unloading conditions. They identified 375 candidate osteokines and analyzed their cellular sources and inter-organ communication regulated by them (bone-brain, liver, and aorta). Full-Text PDF