电穿孔
不可逆电穿孔
免疫疗法
电化学疗法
细胞凋亡
细胞
医学
癌症研究
免疫系统
化学
免疫学
生物化学
基因
作者
Xuan Gong,C. Zhou,Jason J. Hu,Chao Liu
出处
期刊:Vaccines
[MDPI AG]
日期:2022-11-17
卷期号:10 (11): 1942-1942
被引量:6
标识
DOI:10.3390/vaccines10111942
摘要
Electroporation is the process of instantaneously increasing the permeability of a cell membrane under a pulsed electric field. Depending on the parameters of the electric pulses and the target cell electrophysiological characteristics, electroporation can be either reversible or irreversible. Reversible electroporation facilitates the delivery of functional genetic materials or drugs to target cells, inducing cell death by apoptosis, mitotic catastrophe, or pseudoapoptosis; irreversible electroporation is an ablative technology which directly ablates a large amount of tissue without causing harmful thermal effects; electrotherapy using an electric field can induce cell apoptosis without any aggressive invasion. Reversible and irreversible electroporation can also activate systemic antitumor immune response and enhance the efficacy of immunotherapy. In this review, we discuss recent progress related to electroporation, and summarize its latest applications. Further, we discuss the synergistic effects of electroporation-related therapies and immunotherapy. We also propose perspectives for further investigating electroporation and immunotherapy in cancer treatment.
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