二尖瓣反流
心脏病学
医学
内科学
膨胀(度量空间)
二尖瓣
左心房扩大
心房颤动
数学
组合数学
窦性心律
作者
Lukas Stolz,Philipp M. Doldi,Anna Sannino,Jörg Hausleiter,Paul Grayburn
标识
DOI:10.1016/j.jcmg.2024.01.012
摘要
Conflicting results from 2 randomized clinical trials of transcatheter mitral valve edge-to-edge repair in secondary mitral regurgitation (SMR) have led to the recognition that SMR is a heterogeneous disease entity presenting with different functional and morphological phenotypes. This review summarizes the current knowledge on SMR caused primarily by atrial secondary mitral regurgitation (aSMR) and ventricular SMR pathology. Although aSMR is generally characterized by severe left atrial enlargement in the setting of preserved left ventricular anatomy and function, different patterns of mitral annular distortion cause different phenotypes of aSMR. In ventricular SMR, the relation of SMR severity to left ventricular dilation as well as the degree of pulmonary hypertension and right ventricular dysfunction are important phenotypic characteristics, which are key for a better understanding of prognosis and treatment response.
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