Diagnostic and Prognostic Performance of the Modified Lumipulse pTau 181 Assay in Plasma for Alzheimer’s Disease

队列 内科学 生物标志物 医学 疾病 肿瘤科 队列研究 病理 胃肠病学 化学 生物化学
作者
Edward N. Wilson,Christina B. Young,Javier A. Ramos Benitez,Manu Vandijck,Michelle S. Swarovski,Marian Shahid,Nicole K. Corso,Gabriel Kennedy,Alexandra N. Trelle,Divya Channappa,Malia Belnap,Betty Lind,Nathalie Le Bastard,Joseph F. Quinn,Angus C. Nairn,Geoffrey A. Kerchner,Sharon Sha,Anthony D. Wagner,Victor W. Henderson,Frank M. Longo,Tony Wyss‐Coray,Kathleen L. Poston,Elizabeth C. Mormino,Katrin I. Andreasson
出处
期刊:Alzheimers & Dementia [Wiley]
卷期号:18 (S6)
标识
DOI:10.1002/alz.060879
摘要

Abstract Background Recent advances demonstrate utility in blood‐based phosphorylated tau (pTau) as a diagnostic biomarker for Alzheimer’s disease (AD). While several platforms show high diagnostic and prognostic performance, most assays rely on antibody combinations that require long tau peptides for their detection. The Lumipulse G Plasma pTau 181 assay (Fujirebio) instead uses an antibody combination targeting epitopes proximal to Thr181 and therefore can detect shorter tau peptides. This allows for a wider array of expressed plasma pTau 181 peptides to be measured. Method Plasma pTau 181 was measured in three cohorts using the modified Lumipulse G Plasma pTau 181 assay: cohort 1 included 269 cognitively unimpaired (CU), 109 mild cognitively impaired (MCI), and 80 AD participants from the Stanford Alzheimer’s Disease Research Center (ADRC); cohort 2 included 192 CU from the Stanford Aging and Memory Study (SAMS); and cohort 3 a third, independent plasma cohort from the Yale University ADRC included 20 CU and 20 AD participants. Outcome measures included discriminative accuracy of the modified assay for clinical AD diagnosis, association with amyloid and tau pathology determined using CSF biomarkers or positron emission tomography (PET), and ability to predict longitudinal cognitive change. Result Plasma pTau 181 showed robust clinical performance in differentiating AD from CU participants in cohort 1 (AUC = 0.934) and cohort 3 (AUC = 0.845). In cohort 1, the analyte associated with CSF pTau 181 (β=+0.543 and P <0.001), CSF Aβ42/Aβ40 ratio (β=‐0.349 and P <0.001), and amyloid‐PET global SUVRs (β=+0.494 and P <0.001). Associations between plasma P‐tau181 with CSF and PET biomarkers were significant when examined in Aβ+ and Aβ‐ groups separately. Plasma pTau181 was also found to associate with inferior temporal tau‐PET in the subset of CU in cohort 2 (N=35, β=+0.393 and P =0.016). Finally, in cohort 1 baseline plasma pTau 181 predicted change in MoCA over 2‐year follow‐up, controlling for clinical diagnosis, age, sex, and education (β=‐0.211 and P =0.009). Conclusion The results across these 3 participant cohorts revealed the modified Lumipulse G pTau 181 assay discriminates AD pathology in clinical and preclinical AD, strongly associates with CSF and PET imaging in Aβ+ and Aβ‐ participants and predicts longitudinal cognitive decline.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
lxp完成签到,获得积分10
刚刚
果泥关注了科研通微信公众号
1秒前
1秒前
1秒前
太阳完成签到 ,获得积分10
1秒前
1秒前
pkubest发布了新的文献求助10
2秒前
2秒前
量子星尘发布了新的文献求助10
2秒前
MXG发布了新的文献求助30
2秒前
2秒前
shr完成签到,获得积分10
2秒前
Inory007发布了新的文献求助10
4秒前
4秒前
4秒前
ran123456完成签到,获得积分20
4秒前
4秒前
虚心蜗牛发布了新的文献求助10
5秒前
樱悼柳雪发布了新的文献求助10
5秒前
5秒前
动听皮带发布了新的文献求助10
6秒前
热情芝麻发布了新的文献求助10
6秒前
6秒前
6秒前
6秒前
7秒前
zz发布了新的文献求助10
7秒前
7秒前
Eric发布了新的文献求助10
7秒前
Beginner发布了新的文献求助10
7秒前
明帅完成签到,获得积分10
8秒前
zhao发布了新的文献求助10
8秒前
彳亍发布了新的文献求助10
8秒前
晶晶发布了新的文献求助30
9秒前
科研通AI2S应助芜湖采纳,获得10
10秒前
阿蒙发布了新的文献求助10
10秒前
10秒前
jcf完成签到 ,获得积分10
11秒前
阿依努尔发布了新的文献求助10
11秒前
JamesPei应助Rain采纳,获得10
11秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974779
求助须知:如何正确求助?哪些是违规求助? 3519193
关于积分的说明 11197417
捐赠科研通 3255311
什么是DOI,文献DOI怎么找? 1797760
邀请新用户注册赠送积分活动 877150
科研通“疑难数据库(出版商)”最低求助积分说明 806187