化学
部分
催化作用
齿合度
螯合作用
配体(生物化学)
酰胺
组合化学
偶联反应
连接器
抗菌剂
分子
立体化学
金属
有机化学
生物化学
受体
计算机科学
操作系统
作者
Miguel Mateus,Anita Kiss,I. Císařová,Tomasz M. Karpiński,Lukáš Rýček
摘要
We present a synthesis of novel silver complexes stabilized by bidentate ligands based on N ‐heterocyclic carbenes (NHC) linked with a bisamide linker. The ligand stabilizes the silver ion in a rare chelating mode. The synthesis of the complex depends on the equimolar ratio of the silver source and the ligand precursor. In case the excess of the silver source is used, the reaction leads to the formation of an unprecedented tetranuclear silver complex, stabilized by two equivalents of the ligand, where each of the silver atoms is coordinated by one NHC and one amide moiety. The silver complexes were applied as a catalyst in a multicomponent A 3 coupling and proved to be a very efficient catalyst. The reaction provided desired products in yields up to 96%, and the use of low catalytic loading, as low as 0.1 mol%, was possible without significantly compromising the effectivity of the reaction. Moreover, the complexes showed broad spectra of antimicrobial activity, with minimal inhibitory concentrations in the range of 1 to 31 μg/ml against several Gram‐positive and Gram‐negative bacteria and fungi. Presented complexes represent synthetically challenging molecules, which show great applicability in catalysis and outstanding potential as antimicrobial agents.
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