Association of serum uric acid with all-cause and cardiovascular mortality in diabetes: prospective cohort study and meta-analysis

医学 危险系数 糖尿病 全国健康与营养检查调查 内科学 前瞻性队列研究 全国死亡指数 队列 比例危险模型 队列研究 死因 尿酸 荟萃分析 置信区间 疾病 人口 内分泌学 环境卫生
作者
Ben-Chao Li,Liangkai Chen,Xueting Hu,Ting Tan,Jiajia Yang,Wei Bao,Shuang Rong
标识
DOI:10.2337/figshare.21513840
摘要

<p> </p> <p><strong>Objective:</strong> To investigate whether serum uric acid (SUA) level was associated with all-cause and cardiovascular disease (CVD) mortality among individuals with diabetes. </p> <p><strong>Research design and methods: </strong>In this prospective cohort, we included the patients with diabetes from the National Health and Nutritional Examination Survey (NHANES) 1999-2018. Mortality and underlying causes of death were ascertained by linkage to national death records through December 31, 2019. Weighted Cox proportional hazards regression models were used to evaluate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and CVD mortality. We further performed a meta-analysis of available cohort studies to combine the association between SUA and mortality in diabetes.</p> <p><strong>Results: </strong>Among the 7,101 diabetes from NHANES 1999-2018, the weighted mean of SUA level was 5.7 mg/dL. During 57,926 person-years of follow-up, 1,900 deaths (674 deaths from CVD) occurred. In the fully adjusted model, when compared to patients with diabetes in the lowest SUA quintile, those in the highest SUA quintile had the HRs (95% CIs) of 1.28 (1.03, 1.58) for all-cause mortality and 1.41 (1.03, 1.94) for CVD mortality. We included 13 cohort studies in the meta-analysis, and found that the pooled HRs (95% CIs) were 1.08 (1.05, 1.11) for all-cause mortality and 1.05 (1.03, 1.06) for CVD mortality, with per 1 mg/dL increment of SUA level in diabetes. </p> <p><strong>Conclusions:</strong> This study indicated that higher SUA levels were associated with increased risks of all-cause and CVD mortality in diabetes. Interventional studies are needed to elucidate the health effect of lowering uric acid treatments.</p>
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
我是小短腿的妹妹完成签到,获得积分20
刚刚
lily完成签到,获得积分10
刚刚
感谢有你发布了新的文献求助10
2秒前
wh2740完成签到,获得积分10
3秒前
SHAO应助可乐冰淇淋采纳,获得30
6秒前
6秒前
脑洞疼应助JUdy采纳,获得10
8秒前
何白发布了新的文献求助10
8秒前
Lu发布了新的文献求助10
9秒前
hugdoggy完成签到,获得积分10
11秒前
11秒前
桃子发布了新的文献求助30
14秒前
15秒前
Liufgui给风之星的求助进行了留言
15秒前
16秒前
Lucas应助桔子采纳,获得30
18秒前
JUdy发布了新的文献求助10
21秒前
15858833895发布了新的文献求助10
22秒前
许晓蝶完成签到,获得积分10
22秒前
花花完成签到 ,获得积分10
22秒前
wayne完成签到 ,获得积分10
25秒前
25秒前
hua完成签到,获得积分10
26秒前
可乐冰淇淋完成签到,获得积分10
27秒前
27秒前
贝湾完成签到,获得积分10
28秒前
量子星尘发布了新的文献求助10
29秒前
30秒前
水中鱼发布了新的文献求助10
31秒前
lin完成签到,获得积分10
32秒前
陌予完成签到 ,获得积分10
32秒前
33秒前
Fengliguantou发布了新的文献求助20
33秒前
桔子发布了新的文献求助30
33秒前
萨日呼完成签到,获得积分10
33秒前
彭栋完成签到,获得积分10
37秒前
Lu发布了新的文献求助10
37秒前
37秒前
42秒前
桔子完成签到,获得积分10
44秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989115
求助须知:如何正确求助?哪些是违规求助? 3531367
关于积分的说明 11253688
捐赠科研通 3269986
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882078
科研通“疑难数据库(出版商)”最低求助积分说明 809105