免疫系统
免疫疗法
生物
计算生物学
长非编码RNA
免疫检查点
背景(考古学)
黑色素瘤
癌症研究
免疫学
生物信息学
核糖核酸
基因
遗传学
古生物学
作者
Yue Gao,Xiaogang Wang,Longlong Dong,Changfan Qu,Qianyi Lu,Peng Wang,Mengyu Xin,Zheng Wen,Chenyu Liu,Shangwei Ning
标识
DOI:10.1038/s41597-023-02550-z
摘要
Abstract Long non-coding RNAs (lncRNAs) could modulate expression of immune checkpoints (ICPs) in tumor-immune. However, precise functions in immunity and potential for predicting ICP inhibitors (ICI) response have been described for only a few lncRNAs. Here, a multiple-step pipeline was developed to identify cancer- and immune-context ICP and lncRNA cooperative regulation pairs (ICPaLncCRPs) across cancers. Immune-related ICPs and lncRNAs were extracted follow immune cell lines and immunologic constant of rejection groups. ICPaLncCRP networks were constructed, which likely to modulate tumor-immune by specific patterns. Common and specific hub ICPaLncs such as MIR155HG, TRG-AS1 and PCED1B-AS1 maybe play central roles in prognosis and circulating. Moreover, these hub ICPaLncs were significantly correlated with immune cell infiltration based on bulk and single-cell RNA sequencing data. Some ICPaLncCRPs such as IDO1-MIR155HG could predict three- and five-year prognosis of melanoma in two independent datasets. We also validated that some ICPaLncCRPs could effectively predict ICI-response follow six independent datasets. Collectively, this study will enhance our understanding of lncRNA functions and accelerate discovery of lncRNA-based biomarkers in ICI treatment.
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