大流行
疾病
2019年冠状病毒病(COVID-19)
传染病(医学专业)
2019-20冠状病毒爆发
医学
发病机制
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
病毒学
病理
生物
爆发
作者
Fabian Heinrich,Kirsten D. Mertz,Markus Glatzel,Martin Beer,Susanne Krasemann
出处
期刊:Nature microbiology
日期:2023-10-05
卷期号:8 (11): 1986-1994
被引量:4
标识
DOI:10.1038/s41564-023-01488-7
摘要
The emergence of SARS-CoV-2 has resulted in millions of deaths as a result of COVID-19. Suitable models were missing at the beginning of the pandemic, and studies investigating disease pathogenesis relied on patients who had succumbed to COVID-19. Since then, autopsies of patients have substantially contributed to our understanding of the pathogenesis of COVID-19 and associated major organ complications. Here we summarize how autopsies have complemented experimental studies, mainly in animal models, and how they have facilitated critical knowledge of COVID-19 to improve daily clinical practice and develop therapeutic interventions. Employing advanced histopathologic and molecular genetic methods in post-mortem tissues, the COVID-19 pandemic has highlighted the importance of autopsies for virology research and clinical practice in current and emerging infectious diseases. Millions of people have died from SARS-CoV-2. This Review summarizes how autopsies have contributed to our understanding of disease pathology, discusses the advantages and limitations of autopsies, and outlines how they complement animal infection experiments and clinical studies.
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