自噬
痴呆
认知障碍
血管性痴呆
医学
白质
神经科学
认知
生物
内科学
生物化学
精神科
磁共振成像
细胞凋亡
疾病
放射科
作者
Wang Huiyang,Yueyang Liu,Minghui Cui,Zhenkun Guo,Yang Zhao,Jingyu Yang,Chunfu Wu
出处
期刊:Phytomedicine
[Elsevier]
日期:2024-07-26
卷期号:133: 155883-155883
标识
DOI:10.1016/j.phymed.2024.155883
摘要
Vascular dementia (VaD) resulting from chronic cerebral hypoperfusion (CCH) induces cognitive impairment and white matter injury (WMI). We previously found that CCH induces dysfunction of the autophagy-lysosomal pathway (ALP) in white matter (WM) of rats. Enhancing oligodendrocyte autophagy to counteract ALP deficiency is beneficial for cognitive recovery. Pseudogenoside-F11 (PF11), a saponin extracted from Panax quinquefolium l., provides neuroprotective benefits in many animal models of cerebral ischemia and dementia.
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