单线态氧
生物正交化学
光动力疗法
光敏剂
组合化学
化学
光化学
天然产物
有机合成
反应性(心理学)
催化作用
纳米技术
材料科学
氧气
有机化学
点击化学
医学
病理
替代医学
作者
Eleni Nestoros,Fabio De Moliner,Ferran Nadal‐Bufí,Deborah Seah,M. Carmen Ortega‐Liebana,Zhiming Cheng,Sam Benson,Catherine Adam,Larissa Maierhofer,Kostiantyn Kozoriz,Jun‐Seok Lee,Asier Unciti‐Broceta,Marc Vendrell
标识
DOI:10.1038/s41467-024-51872-y
摘要
Abstract Controlling the succession of chemical processes with high specificity in complex systems is advantageous for widespread applications, from biomedical research to drug manufacturing. Despite synthetic advances in bioorthogonal and photochemical methodologies, there is a need for generic chemical approaches that can universally modulate photodynamic reactivity in organic photosensitizers. Herein we present a strategy to fine-tune the production of singlet oxygen in multiple photosensitive scaffolds under the activation of bioresponsive and bioorthogonal stimuli. We demonstrate that the photocatalytic activity of nitrobenzoselenadiazoles can be fully blocked by site-selective incorporation of electron-withdrawing carbamate moieties and restored on demand upon uncaging with a wide range of molecular triggers, including abiotic transition-metal catalysts. We also prove that this strategy can be expanded to most photosensitizers, including diverse structures and spectral properties. Finally, we show that such advanced control of singlet oxygen generation can be broadly applied to the photodynamic ablation of human cells as well as to regulate the release of singlet oxygen in the semi-synthesis of natural product drugs.
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