Adventures in the Chemistry of 1,1-Diacylcyclopropanes

Abstract The present personalized account aims to highlight 1,1-diacylcyclopropanes as synthetic building blocks or target molecules. The chemistry presented includes cyclization reactions of 1,1-diacylcyclopropanes with free and masked dianions to give spirocyclopropanes as products or reactive intermediates that readily undergo ring-cleavage reactions. In addition, the synthesis of cyclopropylated 1,3,5-tricarbonyl compounds, containing two 1,1-diacylcyclopropane moieties, is discussed. Based on this work also other syntheses of cyclopropanes were developed. 1 Introduction 2 Reactions of Masked Dianions 3 Reactions of Free Dianions 4 Cyclopropylated 1,3,5-Tricarbonyl Compounds 5 Miscellaneous 6 Conclusions