肥厚性心肌病
变构调节
肌球蛋白
ATP酶
心肌病
化学
内科学
医学
生物化学
酶
心力衰竭
作者
Nicole Zatorski,Eric A. Sobie,Avner Schlessinger
标识
DOI:10.1016/j.tips.2023.02.005
摘要
STRUCTURE: Mavacamten, 3-(1-methylethyl)-6-[[(1S)-1-phenylethyl]amino]-2,4(1H,3H)-pyrimidinedione, is a reversible small-molecule allosteric inhibitor of cardiac myosin ATPase with a molecular formula of C15H19N3O2 and molecular weight of 273.33 g/mol. It belongs to the pyrimidinedione drug class.
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