阿柏西普
医学
黄斑变性
眼科
眼压
青光眼
新生血管性青光眼
回顾性队列研究
养生
外科
贝伐单抗
化疗
糖尿病性视网膜病变
糖尿病
内分泌学
作者
Junichiro Honjo,Ryo Mukai,Kanako Itagaki,Keiichiro Tanaka,Koki Norikawa,Yutaka Kato,Akihito Kasai,Yukinori Sugano,Tetsuju Sekiryu
出处
期刊:Japanese Journal of Ophthalmology
日期:2024-02-06
卷期号:68 (2): 91-95
标识
DOI:10.1007/s10384-023-01041-3
摘要
To assess the changes in intraocular pressure (IOP) after intravitreal aflibercept injections in Japanese patients with neovascular age-related macular degeneration (nAMD) complicated by glaucoma. Retrospective observational study. We retrospectively reviewed 27 eyes of 25 Japanese patients diagnosed with nAMD complicated by glaucoma. The patients were treated with 2 mg/0.05 ml of aflibercept and followed for 52 weeks according to a treat-and-extend (TAE) regimen after 3 consecutive monthly injections. The IOP of each eye was measured at each visit using non-contact tonometry. IOP changes as well as additional glaucoma treatments during 52 weeks were recorded. The mean of aflibercept injections was 8.3 ± 1.9. The mean IOP at baseline was 14.0 ± 3.1 mmHg, and the mean IOP after aflibercept therapy was 13.0 ± 2.4 mmHg at the final visit (P = 0.0463). No patients received additional glaucoma treatment of eye drops or surgery. Our results suggest that intravitreal aflibercept injections may be beneficial for patients with nAMD complicated by glaucoma.
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