Association between plasma levels of BDNF and GDNF and the diagnosis, treatment response in first-episode MDD

胶质细胞源性神经生长因子 内科学 神经认知 萧条(经济学) 医学 抗抑郁药 心理学 曲线下面积 精神科 神经营养因子 认知 海马体 受体 宏观经济学 经济
作者
Xinyu Liu,Peijun Li,Xiaojuan Ma,Jian Zhang,Xia Sun,Xingguang Luο,Yong Zhang
出处
期刊:Journal of Affective Disorders [Elsevier BV]
卷期号:315: 190-197 被引量:27
标识
DOI:10.1016/j.jad.2022.07.041
摘要

The aims of our study are: i) to explore whether plasma levels of BDNF/GDNF are valuable in the diagnosis of first-episode depression; ii) to discuss whether there is an association between peripheral plasma levels of BDNF/GDNF and patients' depression severity and cognitive dysfunction; iii) to explore the association between plasma levels of BDNF/GDNF and the effectiveness of antidepressant treatment.Ninety patients with first-episode unmedicated MDD and healthy controls were recruited. MDD patients were treated with antidepressant medication for 8 weeks. Patients were assessed for clinical symptoms using HDRS-17 and HAMA-14. Social and neurocognitive functioning of all subjects was assessed at baseline using the Functional Assessment Test Short Form (FAST) and the MATRICS Consensus Cognitive Battery (MCCB). At the same time, peripheral venous blood was drawn from all subjects for BDNF/GDNF peripheral plasma level analysis at baseline and after 8 weeks of treatment.The baseline BDNF/GDNF levels in MDD patients were significantly lower than that in healthy controls. The area under ROC curve (AUC) of baseline plasma BDNF and GDNF levels predicting MDD was 0.776 (95 % CI: 0.705-0.846, p < 0.001) and 0.864 (95 % CI: 0.808-0.920, p < 0.001), respectively. The baseline GDNF level (beta = 0.425, p = 0.001), the autonomy score of FAST (beta = -0.247, p = 0.037) and BACS-SC score of MCCB (beta = 0.323, p = 0.039) were predictors of HDRS-17 reduction rate after 8 weeks' antidepressant treatment.A longer follow-up period than 8 weeks may make the results more convincing, and the sample size of this study is still insufficient.The decreased plasma levels of BDNF and GDNF are strong indicators for predicting the occurrence of MDD. This preliminary finding highlighted the value of GDNF plasma concentrations in the diagnosis of MDD and the prognosis of antidepressant treatment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
河马完成签到,获得积分10
2秒前
单身的钧完成签到,获得积分10
2秒前
3秒前
拉拉霍霍完成签到,获得积分10
3秒前
爱科学完成签到 ,获得积分10
3秒前
Owen应助缥缈八宝粥采纳,获得10
3秒前
称心语风完成签到,获得积分10
4秒前
lin应助十二采纳,获得10
4秒前
4秒前
smoli完成签到 ,获得积分10
4秒前
罗小甜发布了新的文献求助10
4秒前
ayuelei发布了新的文献求助10
4秒前
albert Tesla完成签到,获得积分10
5秒前
5秒前
路途遥远完成签到,获得积分10
5秒前
6秒前
小李发布了新的文献求助10
7秒前
隐形曼青应助DXXX采纳,获得10
7秒前
7秒前
7秒前
8秒前
无花果应助xxxxfiona采纳,获得10
9秒前
在水一方应助IanYoung71采纳,获得10
9秒前
失眠迎松发布了新的文献求助30
9秒前
9秒前
啦啦啦完成签到,获得积分20
9秒前
瓜子发布了新的文献求助20
9秒前
思源应助呆萌代桃采纳,获得10
10秒前
kidult完成签到,获得积分10
12秒前
今后应助抛向天空采纳,获得10
12秒前
学术裁缝发布了新的文献求助10
12秒前
13秒前
烈日骄阳完成签到,获得积分10
13秒前
13秒前
我是老大应助繁星若尘采纳,获得10
14秒前
星辰大海应助Galaxy采纳,获得10
14秒前
研友_Zzy1pn发布了新的文献求助10
14秒前
陈先生完成签到,获得积分10
16秒前
英吉利25发布了新的文献求助10
16秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969458
求助须知:如何正确求助?哪些是违规求助? 3514286
关于积分的说明 11173363
捐赠科研通 3249652
什么是DOI,文献DOI怎么找? 1794948
邀请新用户注册赠送积分活动 875501
科研通“疑难数据库(出版商)”最低求助积分说明 804836