血管平滑肌
动脉硬化
细胞
血小板源性生长因子受体
平滑肌
细胞生物学
医学
化学
内科学
生物
受体
生物化学
生长因子
作者
Shuang Yang,Yixiu Zhao,Shifeng Cao,Xinxin Liu,Min Feng,Yi Chen,Chunyue Ma,Tingting Zhan,Qi Zhang,Honglin Jia,Yu Zhao,Ming Tong,Yuanyuan Yu,Xue Liu,Baofeng Yang,Yan Zhang
出处
期刊:Phytomedicine
[Elsevier]
日期:2024-05-01
卷期号:130: 155704-155704
标识
DOI:10.1016/j.phymed.2024.155704
摘要
Dysregulation of vascular smooth muscle cell (VSMC) function leads to a variety of diseases such as atherosclerosis and hyperplasia after injury. However, antiproliferative drug targeting VSMC exhibits poor specificity. Therefore, there is an urgent to develop highly specific antiproliferative drugs to prevention and treatment VSMC dedifferentiation associated arteriosclerosis. Kanglexin (KLX), a new anthraquinone compound designed by our team, has potential to regulate VSMC phenotype according to the physicochemical properties.
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