内嗅皮质
神经科学
感觉系统
视皮层
视觉系统
刺激(心理学)
海马结构
视觉记忆
空间记忆
计算机科学
生物
认知
工作记忆
心理学
心理治疗师
作者
Qiming Shao,Liang Chen,Xiaowan Li,Miao Li,Han Cui,Xiaoyue Li,Xinran Zhao,Yanting Shi,Qiang Sun,Kaiming Yan,Guangfu Wang
标识
DOI:10.1038/s41467-024-48483-y
摘要
Abstract Visual information is important for accurate spatial coding and memory-guided navigation. As a crucial area for spatial cognition, the medial entorhinal cortex (MEC) harbors diverse spatially tuned cells and functions as the major gateway relaying sensory inputs to the hippocampus containing place cells. However, how visual information enters the MEC has not been fully understood. Here, we identify a pathway originating in the secondary visual cortex (V2) and directly targeting MEC layer 5a (L5a). L5a neurons served as a network hub for visual processing in the MEC by routing visual inputs from multiple V2 areas to other local neurons and hippocampal CA1. Interrupting this pathway severely impaired visual stimulus-evoked neural activity in the MEC and performance of mice in navigation tasks. These observations reveal a visual cortical-entorhinal pathway highlighting the role of MEC L5a in sensory information transmission, a function typically attributed to MEC superficial layers before.
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