Detection and localization of early- and late-stage cancers using platelet RNA

血小板 癌症 核糖核酸 肿瘤分期 阶段(地层学) 医学 癌症分期 无症状的 癌症检测 癌症研究 内科学 肿瘤科 生物 基因 古生物学 生物化学
作者
Sjors G. J. G. In ‘t Veld,Mohammad Arkani,Edward P. Post,Mafalda Antunes-Ferreira,Silvia D’Ambrosi,Daan C.L. Vessies,Lisa Vermunt,Adrienne Vancura,Mirte Muller,Anna-Larissa N. Niemeijer,Jihane Tannous,Laura L. Meijer,Tessa Y. S. Le Large,Giulia Mantini,Niels E. Wondergem,Kimberley M. Heinhuis,Sandra van Wilpe,J. Smits,Esther E.E. Drees,Eva Roos,Cyra E Leurs,Lee-Ann Tjon Kon Fat,Ewoud J. van der Lelij,Govert Dwarshuis,Maarten J. Kamphuis,Lisanne E. Visser,Romée Harting,Annemijn Gregory,Markus Schweiger,Laurine E. Wedekind,Jip Ramaker,Kenn Zwaan,Heleen Verschueren,Idris Bahce,Adrianus J. de Langen,Egbert F. Smit,Michel M. van den Heuvel,Koen J. Hartemink,Marijke J. E. Kuijpers,Mirjam G.A. oude Egbrink,Arjan W. Griffioen,Rafael Rossel,T. Jeroen N. Hiltermann,Elizabeth Lee-Lewandrowski,Kent Lewandrowski,Philip C. De Witt Hamer,Mathilde C.M. Kouwenhoven,Jaap C. Reijneveld,William P. J. Leenders,Ann Hoeben,Irma M. Verdonck‐de Leeuw,C. René Leemans,Robert J. Baatenburg de Jong,Chris H.J. Terhaard,Robert P. Takes,Johannes A. Langendijk,Saskia C.A. de Jager,Adriaan O. Kraaijeveld,Gerard Pasterkamp,Minke Smits,Jack A. Schalken,Sylwia Łapińska‐Szumczyk,Anna Łojkowska,Anna J. Żaczek,Henk M. Lokhorst,Niels W.C.J. van de Donk,Inger S. Nijhof,Henk-Jan Prins,Josée M. Zijlstra,Sander Idema,Johannes C. Baayen,Charlotte E. Teunissen,Joep Killestein,Marc G. Besselink,Lindsay Brammen,Thomas Bachleitner‐Hofmann,Farrah J. Mateen,John Th. M. Plukker,Michal Heger,Quirijn de Mast,Ton Lisman,D. Michiel Pegtel,Harm Jan Bogaard,Jacek Jassem,Anna Supernat,Niven Mehra,Winald R. Gerritsen,Cor D. de Kroon,Christianne Lok,Jurgen M.J. Piek,Neeltje Steeghs,Winan J. van Houdt,Ruud H. Brakenhoff,Gabe S. Sonke,Henk M.W. Verheul,Elisa Giovannetti,Geert Kazemier,Siamack Sabrkhany,Ed Schuuring,Erik A. Sistermans,Rob M.F. Wolthuis,Hanne Meijers‐Heijboer,Josephine C. Dorsman,Cees B.M. Oudejans,Bauke Ylstra,Bart A. Westerman,Daan van den Broek,Danijela Koppers-Lalić,Pieter Wesseling,R. Jonas A. Nilsson,W. Peter Vandertop,David P. Noske,Bakhos A. Tannous,Nik Sol,Myron G. Best,Thomas Würdinger
出处
期刊:Cancer Cell [Elsevier]
卷期号:40 (9): 999-1009.e6 被引量:59
标识
DOI:10.1016/j.ccell.2022.08.006
摘要

Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I–IV cancer patients and in half of 352 stage I–III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
2秒前
CipherSage应助lulu采纳,获得30
2秒前
WYR发布了新的文献求助10
3秒前
我是老大应助吴彦祖采纳,获得10
3秒前
3秒前
4秒前
孝铮完成签到 ,获得积分10
4秒前
深情安青应助cainiansss采纳,获得10
4秒前
5秒前
5秒前
55555发布了新的文献求助20
5秒前
6秒前
JIE发布了新的文献求助10
6秒前
6秒前
隐形曼青应助曹文迪采纳,获得10
6秒前
7秒前
7秒前
7秒前
Bonbon完成签到,获得积分10
7秒前
嘿嘿发布了新的文献求助10
8秒前
小王好饿发布了新的文献求助10
8秒前
清1031发布了新的文献求助10
8秒前
shihui发布了新的文献求助10
9秒前
9秒前
务实如花发布了新的文献求助10
10秒前
10秒前
Bonbon发布了新的文献求助10
10秒前
Yziii应助韦老虎采纳,获得10
10秒前
过分动真发布了新的文献求助10
11秒前
万能图书馆应助青青子衿采纳,获得10
11秒前
23xyke完成签到,获得积分10
12秒前
尛破孩发布了新的文献求助10
13秒前
热情的元芹应助kento采纳,获得50
13秒前
puzhongjiMiQ完成签到,获得积分10
13秒前
14秒前
小二郎应助天元神尊采纳,获得10
14秒前
15秒前
彳亍1117应助简默采纳,获得10
15秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 870
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
Development of general formulas for bolted flanges, by E.O. Waters [and others] 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3255241
求助须知:如何正确求助?哪些是违规求助? 2897673
关于积分的说明 8297638
捐赠科研通 2566741
什么是DOI,文献DOI怎么找? 1393881
科研通“疑难数据库(出版商)”最低求助积分说明 652658
邀请新用户注册赠送积分活动 630306