微生物学
促炎细胞因子
免疫系统
白细胞
生物
先天免疫系统
金黄色葡萄球菌
菌血症
免疫学
炎症
抗生素
细菌
遗传学
作者
Sung Sup Park,Seyong Kwon,Min Goo Lee,Bong Gee Jang,Axel E. Guzmán‐Cedillo,Joo Hyun Kang
出处
期刊:Small
[Wiley]
日期:2022-09-07
卷期号:: 2203746-2203746
标识
DOI:10.1002/smll.202203746
摘要
Bloodstream infection caused by antimicrobial resistance pathogens is a global concern because it is difficult to treat with conventional therapy. Here, scavenger magnetic nanoparticles enveloped by nanovesicles derived from blood cells (MNVs) are reported, which magnetically eradicate an extreme range of pathogens in an extracorporeal circuit. It is quantitatively revealed that glycophorin A and complement receptor (CR) 1 on red blood cell (RBC)-MNVs predominantly capture human fecal bacteria, carbapenem-resistant (CR) Escherichia coli, and extended-spectrum beta-lactamases-positive (ESBL-positive) E. coli, vancomycin-intermediate Staphylococcus aureus (VISA), endotoxins, and proinflammatory cytokines in human blood. Additionally, CR3 and CR1 on white blood cell-MNVs mainly contribute to depleting the virus envelope proteins of Zika, SARS-CoV-2, and their variants in human blood. Supplementing opsonins into the blood significantly augments the pathogen removal efficiency due to its combinatorial interactions between pathogens and CR1 and CR3 on MNVs. The extracorporeal blood cleansing enables full recovery of lethally infected rodent animals within 7 days by treating them twice in series. It is also validated that parameters reflecting immune homeostasis, such as blood cell counts, cytokine levels, and transcriptomics changes, are restored in blood of the fatally infected rats after treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI