剂型
制药工业
计算机科学
设计质量
溶解试验
制药技术
生化工程
生物利用度
工艺工程
工程类
医学
化学
业务
新产品开发
药理学
营销
生物制药分类系统
色谱法
作者
Qi Zeng,Long Wang,Sijun Wu,Guangpu Fang,Mingwei Zhao,Zheng Li,Wenlong Li
标识
DOI:10.1016/j.ijpharm.2022.122100
摘要
Tablet as a traditional dosage form in pharmacy has the advantages of accurate dosage, ideal dissolution and bioavailability, convenient to carry and transport. The most concerned tablet quality attributes include active pharmaceutical ingredient (API) contents and polymorphic forms, components distribution, hardness, density, coating state, dissolution behavior, etc., which greatly affect the bioavailability and consistency of tablet final products. In the pharmaceutical industry, there are usually industry standard methods to analyze the tablet quality attributes. However, these methods are generally time-consuming and laborious, and lack a comprehensive understanding of the properties of tablets, such as spatial information. In recent years, spectral imaging technology makes up for the shortcomings of traditional tablet analysis methods because it provides non-contact and rich information in time and space. As a promising technology to replace the traditional tablet analysis methods, it has attracted more and more attention. The present paper briefly describes a series of spectral imaging techniques and their applications in tablet analysis. Finally, the possible application prospect of this technology and the deficiencies that need to be improved were also prospected.
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