衰老
生物
背景(考古学)
细胞衰老
皮肤老化
人体皮肤
机制(生物学)
信号转导
细胞生物学
医学
表型
遗传学
基因
皮肤病科
古生物学
哲学
认识论
作者
Aleksandra Dańczak‐Pazdrowska,Justyna Gornowicz‐Porowska,Adriana Polańska,Violetta Krajka‐Kuźniak,Maciej Stawny,Aleksandra Gostyńska,Błażej Rubiś,Sarah Nourredine,Sarah Ashiqueali,Augusto Schneider,Tamar Tchkonia,Saranya P. Wyles,James L. Kirkland,Michał M. Masternak
出处
期刊:Aging Cell
[Wiley]
日期:2023-04-11
卷期号:22 (6)
被引量:25
摘要
Abstract Despite the growing interest by researchers into cellular senescence, a hallmark of cellular aging, its role in human skin remains equivocal. The skin is the largest and most accessible human organ, reacting to the external and internal environment. Hence, it is an organ of choice to investigate cellular senescence and to target root‐cause aging processes using senolytic and senomorphic agents, including naturally occurring plant‐based derivatives. This review presents different aspects of skin cellular senescence, from physiology to pathology and signaling pathways. Cellular senescence can have both beneficial and detrimental effects on the skin, indicating that both prosenescent and antisenescent therapies may be desirable, based on the context. Knowledge of molecular mechanisms involved in skin cellular senescence may provide meaningful insights for developing effective therapeutics for senescence‐related skin disorders, such as wound healing and cosmetic skin aging changes.
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