The association between PD-1 / PD-L1 expression and clinicopathological features in sarcomatoid renal cell carcinoma

医学 内科学 比例危险模型 免疫组织化学 肾细胞癌 单变量分析 病态的 精确检验 肿瘤科 多元分析 胃肠病学 病理
作者
Yuan Zhao,Zhongyue Shi,Yao Xie,Ning Li,Hong Chen,Mulan Jin
出处
期刊:Asian Journal of Surgery [Elsevier]
卷期号:47 (1): 163-168
标识
DOI:10.1016/j.asjsur.2023.06.065
摘要

Sarcomatoid renal cell carcinoma (sRCC) accounts for about 4%–5% of all kidney cancers. Previous studies showed that PD-1 and PD-L1 expression was higher in sRCC compared to non-sRCC. In the present study, we aimed to investigate PD-1/PD-L1 expression and its association with clinicopathological features in sRCC. The study included 59 patients diagnosed with sRCC between January 2012 and January 2022. The expression of PD-1 and PD-L1 in sRCC was detected by immunohistochemical staining, and its correlation with clinicopathological parameters was analyzed by χ2 test and Fisher exact test. Kaplan–Meier curves and log-rank tests were used to describe the overall survival (OS). The prognostic significance of clinicopathological parameters on OS was assessed by Cox proportional hazards regression analysis. Among the 59 cases, the positive expression of PD-1 and PD-L1 was 34 cases (57.6%) and 37 cases (62.7%), respectively. PD-1 expression was not significantly correlated with any parameters. However, PD-L1 expression was significantly correlated with tumor size and pathologic T stage. OS was shorter in the subgroup of patients with PD-L1-positive sRCC compared with the PD-L1-negative subgroup. There was no statistically significant difference in OS between PD-1-positive and negative subgroups. According to our study, the univariate and multivariate analysis indicated that pathological T3 and T4 was an independent risk factor in PD-1-positive sRCC. We studied the relationship between PD-1/PD-L1 expression and clinicopathological characteristics in sRCC. The findings may provide valuable implications for clinical prediction.
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