生物医学中的光声成像
化学
光热治疗
磁共振成像
钆
合理设计
免疫疗法
化疗
核磁共振
铜
癌症治疗
癌症
癌症研究
放射科
纳米技术
内科学
医学
光学
有机化学
材料科学
物理
作者
Xueyu Man,Wenjuan Li,Minghui Zhu,Shanhe Li,Gang Xu,Zhenlei Zhang,Hong Liang,Feng Yang
标识
DOI:10.1021/acs.jmedchem.4c01273
摘要
For more accurate diagnosis and effective treatment of cancer, we proposed to develop a hetero-multinuclear metal complex based on the property of apoferritin (AFt) for targeting tumor theranostics by integrating dual-modality imaging diagnosis and multimodality therapy. To this end, we rational designed and synthesized a trinuclear Gd(III)–Cu(II) thiosemicarbazone complex (Gd-2Cu) and then constructed a Gd-2Cu@AFt nanoparticle (NP) delivery system. Gd-2Cu/Gd-2Cu@AFt NPs not only had significant T1-weighted magnetic resonance imaging and photoacoustic imaging of the tumor but also effectively inhibited tumor growth through a combination of mild photothermal therapy, chemotherapy, and immunotherapy. Gd-2Cu@AFt NPs optimized the behavior of imaging diagnosis and therapy of Gd-2Cu, improved its targeting ability, and reduced the side effects in vivo. Besides, we revealed and clarified the anticancer mechanism of Gd-2Cu: interrupting energy metabolism of the tumor cell, inducing apoptosis of the tumor cell, and activating a systemic immune response by inducing immunogenic cell death of cancer cells.
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