生物医学中的光声成像
化学
光热治疗
磁共振成像
钆
合理设计
免疫疗法
体内
化疗
核磁共振
癌细胞
癌症治疗
癌症
癌症研究
放射科
纳米技术
内科学
医学
光学
材料科学
物理
有机化学
生物技术
生物
作者
Xueyu Man,Wenjuan Li,Minghui Zhu,Shanhe Li,Gang Xu,Zhenlei Zhang,Hong Liang,Feng Yang
标识
DOI:10.1021/acs.jmedchem.4c01273
摘要
For more accurate diagnosis and effective treatment of cancer, we proposed to develop a hetero-multinuclear metal complex based on the property of apoferritin (AFt) for targeting tumor theranostics by integrating dual-modality imaging diagnosis and multimodality therapy. To this end, we rational designed and synthesized a trinuclear Gd(III)–Cu(II) thiosemicarbazone complex (Gd-2Cu) and then constructed a Gd-2Cu@AFt nanoparticle (NP) delivery system. Gd-2Cu/Gd-2Cu@AFt NPs not only had significant T1-weighted magnetic resonance imaging and photoacoustic imaging of the tumor but also effectively inhibited tumor growth through a combination of mild photothermal therapy, chemotherapy, and immunotherapy. Gd-2Cu@AFt NPs optimized the behavior of imaging diagnosis and therapy of Gd-2Cu, improved its targeting ability, and reduced the side effects in vivo. Besides, we revealed and clarified the anticancer mechanism of Gd-2Cu: interrupting energy metabolism of the tumor cell, inducing apoptosis of the tumor cell, and activating a systemic immune response by inducing immunogenic cell death of cancer cells.
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