Drug‐associated glaucoma: A real‐world study based on the Food and Drug Administration adverse event reporting system database

医学 不良事件报告系统 药品 不利影响 内科学 药理学
作者
Shi‐Nan Wu,Xiaohong Chen,Dan Yan,Yuqian Wang,Shaopan Wang,Wenying Guan,Caihong Huang,Jiaoyue Hu,Zuguo Liu
出处
期刊:Clinical and Experimental Ophthalmology [Wiley]
被引量:2
标识
DOI:10.1111/ceo.14454
摘要

Abstract Background This study aims to assess the risk of drug‐associated glaucoma and track its epidemiological characteristics using real‐world data. Methods Adverse event reports from the Food and Drug Administration Adverse Event Reporting System (FAERS) from January 2004 to December 2023 were analysed. Disproportionality analysis and the Bayesian Confidence Propagation Neural Network algorithm were used. The study classified drugs associated with glaucoma, assessed risk levels, and compared drug‐induced times across different categories. Results Eight hundred and five drugs were linked to glaucoma in the FAERS database. Disproportionality analysis identified 46 drugs with significant risk, mainly adrenergic medications (clobetasol propionate, fluocinolone acetonide), antihypertensives (hydrochlorothiazide), insulin (insulin human), anticholinergics (umeclidinium, darifenacin), VEGF inhibitors (brolucizumab, faricimab), and psychotropics (topiramate, ziprasidone). The top three high‐risk drugs were clobetasol propionate, umeclidinium, and fluocinolone acetonide. The shortest drug‐induced times were observed with indacaterol, salmeterol, and umeclidinium. Anticholinergic medications had the shortest drug‐induced time among all categories. Females (62.5%) and the elderly (average age 63.5 ± 16.8 years) were predominantly affected. Reports of drug‐associated glaucoma increased over the years. Conclusion Preventing drug‐associated glaucoma is more effective than treatment. Identifying the risk and drug‐induced times of systemic and ophthalmic drugs can reduce occurrence risk. Clinical practitioners should be vigilant and inform patients of these risks.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Perry应助科研通管家采纳,获得30
刚刚
刚刚
刚刚
刚刚
秘小先儿完成签到,获得积分10
1秒前
小谢完成签到,获得积分10
4秒前
lemongulf完成签到 ,获得积分10
4秒前
4秒前
王小西完成签到,获得积分10
5秒前
zzx完成签到,获得积分10
5秒前
量子星尘发布了新的文献求助50
8秒前
学术乞丐发布了新的文献求助10
11秒前
万能图书馆应助怡然问晴采纳,获得10
11秒前
Akim应助体贴凌柏采纳,获得10
12秒前
zyq完成签到,获得积分10
13秒前
西瓜完成签到,获得积分10
14秒前
xshzhou完成签到,获得积分10
16秒前
苗条白枫完成签到 ,获得积分10
17秒前
一棵草完成签到,获得积分10
17秒前
内向的跳跳糖完成签到,获得积分10
17秒前
遇见飞儿完成签到,获得积分0
17秒前
cream完成签到,获得积分20
18秒前
18秒前
小薛完成签到,获得积分10
18秒前
19秒前
Cu_wx完成签到,获得积分10
19秒前
噜噜噜噜噜完成签到,获得积分10
21秒前
赵慧霞关注了科研通微信公众号
21秒前
炎魔之王拉格纳罗斯完成签到,获得积分10
22秒前
内向苡完成签到,获得积分10
23秒前
以筱发布了新的文献求助10
25秒前
bhkwxdxy完成签到,获得积分10
26秒前
悦耳虔纹完成签到 ,获得积分10
26秒前
xx完成签到,获得积分10
26秒前
大气灵枫完成签到,获得积分10
26秒前
妮妮完成签到,获得积分10
27秒前
29秒前
Struggle完成签到 ,获得积分10
30秒前
30秒前
秦兴虎完成签到,获得积分10
31秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038303
求助须知:如何正确求助?哪些是违规求助? 3576013
关于积分的说明 11374210
捐赠科研通 3305780
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029