对偶(语法数字)
按需
材料科学
听力损失
声学
纳米技术
听力学
物理
医学
计算机科学
艺术
多媒体
文学类
作者
Xinyang Yi,Lifang Guo,Qi Zeng,Suling Huang,Dingsheng Wen,Chu Wang,Yuwei Kou,Ming Zhang,Huaan Li,Lu Wen,Gang Chen
出处
期刊:Small
[Wiley]
日期:2024-07-17
被引量:2
标识
DOI:10.1002/smll.202401369
摘要
Multidrug combination therapy in the inner ear faces diverse challenges due to the distinct physicochemical properties of drugs and the difficulties of overcoming the oto-biologic barrier. Although nanomedicine platforms offer potential solutions to multidrug delivery, the access of drugs to the inner ear remains limited. Micro/nanomachines, capable of delivering cargo actively, are promising tools for overcoming bio-barriers. Herein, a novel microrobot-based strategy to penetrate the round window membrane (RWM) is presented and multidrug in on-demand manner is delivered. The tube-type microrobot (TTMR) is constructed using the template-assisted layer-by-layer (LbL) assembly of chitosan/ferroferric oxide/silicon dioxide (CS/Fe
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