丝氨酸
信号转导
表型
苏氨酸
抄写(语言学)
细胞生物学
化学
转录因子
基因
翻译(生物学)
磷酸化
生物
神经科学
生物化学
信使核糖核酸
语言学
哲学
作者
Batuhan Uygar,Olof Lagerlöf
出处
期刊:Advances in neurobiology
日期:2022-10-19
卷期号:: 255-280
被引量:3
标识
DOI:10.1007/978-3-031-12390-0_9
摘要
O-GlcNAc is the attachment of β-N-acetylglucosamine to the hydroxyl group of serine and threonine in nuclear and cytoplasmic proteins. It is generally not further elongated but exists as a monosaccharide that can be rapidly added or removed. Thousands of proteins involved in gene transcription, protein translation and degradation as well as the regulation of signal transduction contain O-GlcNAc. Brain is one of the tissues where O-GlcNAc is the most highly expressed and deletion of neuronal O-GlcNAc leads to death early in development. O-GlcNAc is also important for normal adult brain function, where dynamic processes like learning and memory at least in part depend on the modification of specific proteins by O-GlcNAc. Conversely, too much or too little O-GlcNAc in the brain contributes to several disorders including obesity, intellectual disability and Alzheimer's disease. In this chapter, we describe the expression and regulation of O-GlcNAc in the nervous system.
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