Effects of perchlorate, nitrate, and thiocyanate exposures on serum total testosterone in children and adolescents

高氯酸盐 硫氰酸盐 泌尿系统 睾酮(贴片) 人口 硝酸盐 内科学 内分泌学 尿 化学 医学 生理学 生物化学 环境卫生 有机化学 离子
作者
Yingying Han,Dandan Li,Chenxi Zou,Yonggang Li,Feng Zhao
出处
期刊:Science of The Total Environment [Elsevier BV]
卷期号:861: 160566-160566 被引量:9
标识
DOI:10.1016/j.scitotenv.2022.160566
摘要

Perchlorate, nitrate, and thiocyanate are common thyroid disruptors in daily life and alter testosterone levels in animals. However, little is known about the effects of perchlorate, nitrate, and thiocyanate on serum total testosterone (TT) in the general population. The study was designed to assess the associations between urinary levels of perchlorate, nitrate, and thiocyanate and serum total testosterone (TT) in the general population. The present study utilized data from the 2011-2016 National Health and Nutritional Examination Survey (NHANES). A total of 6201 participants aged 6-79 with information on urinary perchlorate, nitrate, thiocyanate, and serum total testosterone were included. We conducted multiple linear regression models and Bayesian Kernel Machine Regression (BKMR) models to estimate the associations by sex-age groups. Children (ages 6-11) have higher levels of perchlorate and nitrate than the rest. After adjusting for covariates, urinary perchlorate was significantly negatively associated with serum TT in male adolescents (β = -0.1, 95 % confidence interval: -0.2, -0.01) and female children [-0.13, (-0.21, -0.05)]. Urinary nitrate was significantly negatively associated with serum TT in female children, while urinary thiocyanate was significantly positively associated with serum TT in female adults aged 20 to 49 [0.05 (0.02, 0.08)]. BKMR analysis indicated that no other interactions were found between urinary perchlorate, nitrate, and thiocyanate. Our findings suggested that urinary perchlorate, nitrate, and thiocyanate levels may relate to serum total testosterone levels in specific sex-age groups. We identified male adolescents and female children as are most sensitive subgroups where testosterone is susceptible to interference.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
华仔应助科研通管家采纳,获得10
刚刚
Owen应助科研通管家采纳,获得10
刚刚
SYLH应助科研通管家采纳,获得20
刚刚
思源应助科研通管家采纳,获得10
刚刚
李健应助科研通管家采纳,获得10
刚刚
ding应助科研通管家采纳,获得10
刚刚
酷波er应助科研通管家采纳,获得10
刚刚
SciGPT应助科研通管家采纳,获得10
1秒前
CodeCraft应助科研通管家采纳,获得10
1秒前
1秒前
1秒前
赘婿应助科研通管家采纳,获得10
1秒前
1秒前
1秒前
1秒前
wang发布了新的文献求助10
1秒前
1秒前
jinxli完成签到 ,获得积分10
2秒前
3秒前
封迎松完成签到 ,获得积分10
4秒前
小李子发布了新的文献求助10
4秒前
ZengJuan发布了新的文献求助10
4秒前
所所应助zy采纳,获得10
6秒前
华仔应助科多兽骑士采纳,获得30
7秒前
7秒前
赘婿应助tuyoyo采纳,获得10
8秒前
啦啦啦完成签到,获得积分10
8秒前
GS11完成签到,获得积分10
8秒前
Lucas应助麒麟采纳,获得20
9秒前
温暖冬日完成签到,获得积分10
9秒前
EED发布了新的文献求助10
9秒前
葡萄发布了新的文献求助30
10秒前
小骁同学完成签到,获得积分10
10秒前
朏朏完成签到,获得积分10
11秒前
5km完成签到,获得积分10
12秒前
wanci应助爱学习的曼卉采纳,获得10
12秒前
12秒前
14秒前
15秒前
Theprisoners应助吗喽采纳,获得20
15秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Indomethacinのヒトにおける経皮吸収 400
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 370
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
Current Perspectives on Generative SLA - Processing, Influence, and Interfaces 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3992562
求助须知:如何正确求助?哪些是违规求助? 3533545
关于积分的说明 11262757
捐赠科研通 3273163
什么是DOI,文献DOI怎么找? 1805959
邀请新用户注册赠送积分活动 882889
科研通“疑难数据库(出版商)”最低求助积分说明 809513