黄芩素
活性氧
抗氧化剂
过氧化氢酶
氧化还原
氧化应激
平衡
材料科学
药理学
生物物理学
化学
医学
生物化学
内科学
无机化学
生物
作者
Kaijing Liu,Limei Liu,Haoyang Guo,Rong Xu,Xiaoyu Liang,Youlu Chen,Huiyang Li,Xue Fu,Xiaoli Wang,Hou‐Zao Chen,Yongjun Li,Jing Wang
标识
DOI:10.1002/adhm.202202010
摘要
Reactive oxygen species (ROS) have been implicated in multiple cellular processes, and an imbalance in redox homeostasis gives rise to diseases, therefore, reestablishing redox homeostasis is a way to cure. Here, copper-based metal-organic networks (Cu-MON) are generated by one-step reaction using anti-inflammatory and antioxidant baicalein as organic ligand and pro-angiogenic copper as metal ions. Phosphate buffered saline is required for triggering Cu-MON formation, and baicalein regulates the morphology and particle size of Cu-MON. Cu-MON are composed of Cu-baicalein complexes (82.08 wt%) and Cu3 (PO4 )2 ·3H2 O (17.92 wt%), thus exhibit a variable catalase-like activity against different H2 O2 levels due to the reversible change between Cu2+ /Cu1+ /Cu0 species. Intramuscular injection of Cu-MON significantly increases blood flow of ischemic limb in diabetic mice, enhances the relative activities of redox-related enzymes in ischemic muscle, thus effectively ameliorating the oxidative damage. Taken together, through moderate and dynamic "precise homeostasis regulation of cells," Cu-MON can be an efficient therapeutic strategy for peripheral arterial disease with diabetic complications.
科研通智能强力驱动
Strongly Powered by AbleSci AI