The assessment of the static and dynamic behaviour of historic masonry towers, together with the development of proper preservation strategies, has attracted in recent decades the interest of a plethora of scholars. Most of the studies focus on the assessment of their seismic behaviour since their slenderness exposes them to the dynamic effects induced by medium-to-severe earthquakes. This paper, which is framed in this background, discusses on a preliminary identification of the seismic behaviour of Giotto’s bell tower in Florence, one of the iconic masonry towers ever built in Italy. In the first part of this paper, a summary of the available information on this bell tower is provided. Next, a refined numerical model, built through the finite element technique, and based on a recent laser scanning survey, is reported and employed to investigate its seismic behaviour. The numerical model accounts (in a simplified way) for the soil-structure-interaction, and scaled natural accelerograms selected based on the Florence seismic hazard are considered to develop linear and nonlinear time-history analyses. The results allow an initial assessment of the seismic behaviour of Giotto’s bell tower suggesting both future in-depth investigations and analyses, together with proper preservation strategies.