Dexamethasone Versus Placebo in the Prophylaxis of Radiation-induced Pain Flare Following Palliative Radiation Therapy for Bone Metastases: A Double-blind Randomized, Controlled, Superiority Trial

Pain flare occurs following palliative radiation therapy, and dexamethasone has shown potential for preventing such a flare. This double-blind study compared dexamethasone to placebo in reducing the incidence of pain flare with secondary endpoints of toxicity and impact on quality of life.