肺炎克雷伯菌
整合子
微生物学
流动遗传元素
转座因子
碳青霉烯
生物
医学
基因
抗生素
抗生素耐药性
遗传学
大肠杆菌
质粒
基因组
作者
Alessandra Piccirilli,Mariagrazia Perilli,Valentina Piccirilli,Bernardetta Segatore,Gianfranco Amicosante,L. Maccacaro,Alda Bazaj,Laura Naso,Giuliana Lo Cascio,Giuseppe Cornaglia
标识
DOI:10.1016/j.diagmicrobio.2019.114968
摘要
Klebsiella pneumoniae strain is an important opportunistic pathogen that causes severe nosocomial infections. In the present study a molecular characterization of carbapenem resistant K. pneumoniae, isolated from blood samples of hospitalized patients of Verona University Hospital, was performed. The simultaneous presence of SHV-1/CTX-M-15/KPC-3 and SHV-1/CTX-M-15/OXA-48 serin-β-lactamases was ascertained in the 89% and 11% of K. pneumoniae ST512 and K. pneumoniae ST14, respectively. Molecular characterization of bla genes showed that blaKPC-3 was found in Tn4401a transposon with the tnpR, tnpA, ISKpn6, and ISKpn7 mobile elements whereas blaCTX-M-15 was detected downstream ISEcp1 genetic element. A class 1 integron with a gene cassette of 780 bp corresponding to aadA2 gene was identified in 33 K. pneumoniae ST512 isolates.
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