HER-2 Amplification in Uterine Serous Carcinoma and Serous Endometrial Intraepithelial Carcinoma

免疫组织化学 浆液性液体 医学 浆液性癌 荧光原位杂交 病理 孕酮受体 乳腺癌 乳腺癌 肿瘤科 内科学 癌症 生物 雌激素受体 卵巢癌 基因 生物化学 染色体
作者
Natalie Banet,Maryam Shahi,Denise Batista,Raluca Yonescu,Edward J. Tanner,Amanda N. Fader,Ashley Cimino‐Mathews
出处
期刊:The American Journal of Surgical Pathology [Lippincott Williams & Wilkins]
卷期号:45 (5): 708-715 被引量:16
标识
DOI:10.1097/pas.0000000000001682
摘要

Human epidermal growth factor receptor 2 (HER-2) targeted therapy shows promising results in HER-2-positive uterine serous carcinoma (USC). HER-2 scoring criteria for USC and its associated noninvasive lesion, serous endometrial intraepithelial carcinoma (SEIC), are not well-established. Here, we compare the breast and gastric (GI) HER-2 immunohistochemistry (IHC) scoring criteria for HER-2 with HER-2/neu fluorescence in situ hybridization (FISH) in 68 tumors (17 USC with SEIC, 30 USC, 18 SEIC, 3 metastatic USC). The majority (97%) of lesions displayed intratumoral HER-2 IHC heterogeneity. Breast or GI IHC scoring criteria were performed equivalently. The breast and GI IHC criteria classified 51% and 47% USC as HER-2 negative (IHC 0/1+), 40% and 45% as equivocal (IHC 2+), and 9% each as HER-2 positive (IHC 3+). A quarter of USC classified as HER-2 negative or positive with the breast (25%, n=7/28) or GI IHC criteria (23%, n=6/26) was discordant by FISH. Specifically, 13% to 14% of IHC 0/1+ USC were FISH amplified; 50% of IHC 3+ USC were FISH negative. The majority (77% to 83%) of SEIC were HER-2 IHC 0/1+, and no SEIC was HER-2 IHC 3+. A minority (4% to 7%) of IHC 0/1+ SEIC were FISH positive. Discordant HER-2 status was observed between half (47%,bn=7/15) of synchronous SEIC and USC. In conclusion, USC displays HER-2 intratumoral heterogeneity, a high IHC/FISH discordance rate, and variation in HER-2 status between the SEIC and invasive components. Caution is required when evaluating HER-2 in small biopsies, which should be repeated on excisions. Both IHC and FISH should be performed on USC until clinical trials correlate HER-2 status with clinical response to HER-2-targeted therapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
情怀应助Rason采纳,获得10
1秒前
量子星尘发布了新的文献求助30
1秒前
2秒前
冯诗樱发布了新的文献求助20
3秒前
3秒前
曦小蕊发布了新的文献求助10
3秒前
wjx发布了新的文献求助10
4秒前
5秒前
5秒前
Emmmm完成签到,获得积分10
5秒前
LLLLL发布了新的文献求助10
6秒前
7秒前
刘萄发布了新的文献求助10
7秒前
小王完成签到,获得积分10
7秒前
香蕉觅云应助Even采纳,获得10
7秒前
7秒前
典雅碧空发布了新的文献求助10
8秒前
ZZ发布了新的文献求助10
9秒前
火柴发布了新的文献求助10
9秒前
10秒前
BY0131完成签到,获得积分20
10秒前
hhj完成签到,获得积分10
10秒前
允柠关注了科研通微信公众号
10秒前
PengHu完成签到,获得积分10
11秒前
千万雷同发布了新的文献求助10
11秒前
留白发布了新的文献求助10
12秒前
隐形曼青应助1256采纳,获得10
12秒前
zzjjzzjj完成签到,获得积分10
12秒前
幸运草完成签到,获得积分10
12秒前
思源应助wangdafa采纳,获得10
13秒前
13秒前
shuiyu完成签到,获得积分10
14秒前
15秒前
15秒前
李爱国应助科研通管家采纳,获得10
15秒前
大个应助科研通管家采纳,获得10
15秒前
领导范儿应助科研通管家采纳,获得10
15秒前
星辰大海应助科研通管家采纳,获得50
15秒前
Jasper应助科研通管家采纳,获得10
15秒前
柏林寒冬应助科研通管家采纳,获得10
15秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974882
求助须知:如何正确求助?哪些是违规求助? 3519431
关于积分的说明 11198315
捐赠科研通 3255698
什么是DOI,文献DOI怎么找? 1797904
邀请新用户注册赠送积分活动 877237
科研通“疑难数据库(出版商)”最低求助积分说明 806219