Biomarkers in VSMC phenotypic modulation and vascular remodeling.

Vascular smooth muscle cells (VSMCs) are not terminally differentiated and can change their phenotype in response to environmental cues. Phenotype switching of VSMCs to less differentiated forms has led to an underestimation of their role in the development of vascular remodeling and many vascular diseases in both humans and animal models of this disease. In recent studies, many factors, such as microRNAs, matrix metalloproteinases, integrins, oxidative stress, autophagy, have been shown to play important roles in the mechanisms of VSMC phenotypic switch and vascular remodeling. This review highlights the current knowledge regarding the molecular mechanisms of VSMC phenotypic modulation in vascular remodeling. In this review, we want to provide effective molecular targets and opportunities for the future development of new therapeutics to regulate vascular remodeling diseases.