Molecular crowding effects on the biochemical properties of amyloid β–heme, Aβ–Cu and Aβ–heme–Cu complexes

Our findings highlight the significance of hydration contributions to the interactions of Aβ–heme and Aβ–Cu as well as their peroxidase activities. Aβ40–Cu but not Aβ40–heme may play more important roles in the oxidative damage in the etiology of AD.